Ovarian Histological Structure and Components

Medullary and Stromal Elements

• The medulla contains loose connective tissue stroma with abundant blood vessels and lymphatics, as well as hilar cells (Leydig-like cells) that may be present near the ovarian hilum, according to the American Society of Clinical Oncology 1
• The ovarian stroma undergoes continuous transformation, including sex cord-stromal derivatives such as granulosa cells, thecal cells, Sertoli cells, and Leydig cells that arise from embryonic gonadal sex cords, as reported by the American Society of Clinical Oncology 1, 2