Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/23/2025

Allergic Reactions to Semaglutide

Contraindications and Warnings

  • Semaglutide is contraindicated in patients with a history of serious hypersensitivity reaction to the drug, as recommended by the American College of Cardiology 1, 2
  • The American College of Cardiology also warns of a risk of diabetic retinopathy complications, particularly in patients with pre-existing retinopathy 1

Adverse Reactions

  • Gastrointestinal side effects are the most common adverse reactions, including nausea, vomiting, diarrhea, and dyspepsia, according to the Anaesthesia guideline society 3
  • There is an increased risk of gallbladder disorders including cholelithiasis, as reported by the Anaesthesia guideline society 3