Alprazolam-Associated Nightmares

Evidence of Alprazolam and Nightmares

• Medication effects on dream content can be a clinically significant issue, as one patient discontinued treatment due to "more vivid nightmares" in a retrospective cohort study of trazodone use for PTSD-related nightmares, suggesting that benzodiazepines like alprazolam may have similar effects 1, 2

Clinical Considerations

• The American Academy of Sleep Medicine suggests that the timing of administration may be important, and taking benzodiazepines later in the day might have more pronounced effects on sleep architecture and dream content, which may be relevant for alprazolam use 1