Mechanism and Clinical Implications of Hydralazine

Pharmacological Effects

• The American Heart Association suggests that hydralazine may help prevent nitrate tolerance when combined with nitrates, such as isosorbide dinitrate, due to its potential antioxidative properties 1, 2
• The combination of hydralazine with nitrates, such as isosorbide dinitrate, is often used in heart failure treatment, as the direct arterial vasodilation with minimal venous effects explains the therapeutic benefits of this combination 1, 2, 3