Tramadol Dosing and Administration

Adult Dosing Recommendations

• The National Comprehensive Cancer Network recommends standard dosing of 50-100mg every 4-6 hours as needed for pain, with a maximum daily dose of 400mg for immediate-release formulations 1, 2, 3
• For extended-release formulations, the maximum daily dose is 300mg 3

Important Precautions

• The National Comprehensive Cancer Network advises that tramadol should be avoided in patients taking selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants due to the risk of serotonin syndrome 1, 3
• Common adverse effects of tramadol include dizziness 1, sedation 3, vomiting 3, and weakness [3] [1, 3]

Pediatric Dosing

• The Anaesthesia journal recommends a dose of 1 to 1.5 mg/kg every 4 to 6 hours for children in postoperative settings 2, 4
• For breakthrough pain in pediatric wards, the recommended dose is 1 to 1.5 mg/kg every 4 to 6 hours 4