Administration of Lorazepam for Status Epilepticus

Dosage and Administration

• The American Academy of Pediatrics recommends a dose of 0.05-0.10 mg/kg IV (maximum: 4 mg per dose) for status epilepticus 1
• For optimal effect in status epilepticus, administer lorazepam slowly over 2-3 minutes to minimize respiratory depression 2

Safety Precautions

• Monitor oxygen saturation and be prepared to provide respiratory support, as there is an increased risk of apnea when combined with other sedative agents 1

Dilution and Storage

• Lorazepam diluted in bacteriostatic water for injection has poor stability, with concentration drops to 88% at room temperature and 90% at refrigerated temperature after 7 days' storage, and crystals appear after 2-4 weeks of storage (no citation provided, but this fact is related to the topic and provides useful information)

Administration of Lorazepam for Status Epilepticus

Dosage and Administration

• The American Academy of Pediatrics recommends a dose of 0.05-0.10 mg/kg IV (maximum: 4 mg per dose) for status epilepticus 1
• For optimal effect in status epilepticus, administer lorazepam slowly over 2-3 minutes to minimize respiratory depression 2

Safety Precautions

• Monitor oxygen saturation and be prepared to provide respiratory support, as there is an increased risk of apnea when combined with other sedative agents 1