Empagliflozin Use in Pregnancy

Introduction to Empagliflozin and Pregnancy

• Empagliflozin should be discontinued at least 6 weeks before attempting conception to minimize potential risks to the fetus, as recommended by the American Association for the Study of Liver Diseases 1

Preconception Planning

• The American Association for the Study of Liver Diseases provides guidance that empagliflozin should be discontinued at least 6 weeks before conception, allowing for complete elimination of the drug from the body, reduction of potential risks to early fetal development, and transition to alternative diabetes management if needed 1

Discontinuation and Alternative Management

• When discontinuing empagliflozin before pregnancy, it is essential to consult with healthcare providers, discuss alternative diabetes management, and establish optimal glycemic control before conception, as poorly controlled diabetes increases risks of complications 1

Post-Discontinuation Care

• Regular blood glucose monitoring is essential after stopping empagliflozin to maintain glycemic control, and preparation should be made for possible deterioration in glycemic control after discontinuation 1

Resumption of Empagliflozin

• Empagliflozin can be considered for resumption after pregnancy is complete and breastfeeding has ended, although the decision should be made with consideration of the individual's health status and medical history 1