Steroids and Sleep Disturbances

Introduction to Steroid-Induced Sleep Disturbances

Steroids can cause sleep disturbances, including sleep deprivation, with sleep disturbances reported to occur in more than 30% of patients taking corticosteroids, according to the American Academy of Otolaryngology-Head and Neck Surgery 1, 2

Sleep disturbances are among the most common adverse effects of corticosteroid therapy, occurring at an incidence of >30% in patients taking corticosteroids, as reported by the American Academy of Otolaryngology-Head and Neck Surgery 1, 2, 3
Sleep disturbances are listed among the documented side effects of both short-term and long-term steroid therapy, as noted by the American Academy of Otolaryngology-Head and Neck Surgery 1, 4

Higher doses of corticosteroids are associated with increased risk of adverse effects, including sleep disturbances, according to the American Academy of Otolaryngology-Head and Neck Surgery 2, 3
Even short courses (<21 days) of oral steroids can increase the risk of insomnia, as reported by the American Academy of Otolaryngology-Head and Neck Surgery 2

Use the lowest effective dose for the shortest duration possible to minimize sleep disruption, as recommended by the American Academy of Otolaryngology-Head and Neck Surgery 2, 3
Implement good sleep hygiene practices, including regular sleep schedules, avoiding caffeine and alcohol near bedtime, and creating a comfortable sleep environment, as suggested by the National Comprehensive Cancer Network 5
Consider referral to a sleep specialist if sleep disturbances are severe or persistent, as recommended by the National Comprehensive Cancer Network 5

Inform patients about the potential for sleep disturbances as a common side effect of corticosteroid therapy, as advised by the American Academy of Otolaryngology-Head and Neck Surgery 1, 2
Weigh the benefits of corticosteroid therapy against the risks, including sleep disturbances, as recommended by the American Academy of Otolaryngology-Head and Neck Surgery 2, 3
Monitor patients for signs of sleep deprivation, which may impact quality of life and treatment adherence, as noted by the American Society of Hematology 6