Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/20/2025

Guidelines for Preventing Catheter-Associated Urinary Tract Infections

Indications and Contraindications for Bladder Irrigation

  • Bladder irrigation with antiseptics may be beneficial in specific surgical scenarios, such as for patients undergoing transurethral operations, where chlorhexidine irrigation has shown to reduce postoperative catheter-associated bacteriuria 1
  • Routine bladder irrigation with antimicrobials or antiseptics should not be used to reduce catheter-associated bacteriuria or catheter-associated urinary tract infections in general catheterized patients, as recommended by the Infectious Diseases Society of America 1, 2
  • The use of topical antiseptics or antimicrobials on the catheter, urethra, or meatus is not recommended, according to the Journal of Microbiology, Immunology and Infection 2

Procedure for Necessary Bladder Irrigation

  • When bladder irrigation is clinically indicated, obtain a urine culture prior to the procedure to guide targeted antimicrobial therapy, as suggested by the Clinical Infectious Diseases journal 3, 4
  • For surgical procedures with mucosal trauma, treat catheter-associated asymptomatic bacteriuria before the procedure, as recommended by the Journal of Microbiology, Immunology and Infection 2
  • Administer the irrigation solution 30-60 minutes before the procedure, according to the Clinical Infectious Diseases journal 4

Special Considerations

  • For patients undergoing endoscopic urologic procedures associated with mucosal trauma, screen for and treat asymptomatic bacteriuria prior to surgery, as recommended by the Clinical Infectious Diseases journal 4
  • Use a short course (1 or 2 doses) rather than prolonged antimicrobial therapy for patients undergoing endoscopic urologic procedures, as suggested by the Clinical Infectious Diseases journal 4
  • Replace or remove the indwelling catheter before starting antimicrobial therapy for symptomatic catheter-associated urinary tract infections, as recommended by the Journal of Microbiology, Immunology and Infection 2
  • Minimize the duration of catheterization to reduce infection risk, according to the Journal of Microbiology, Immunology and Infection 2
  • Use hydrophilic coated catheters to reduce catheter-associated urinary tract infections, as recommended by the Journal of Microbiology, Immunology and Infection 2

Evidence Against Routine Bladder Irrigation

  • Studies have shown that routine bladder irrigation with neomycin-polymyxin, acetic acid, or saline has no effect on catheter-associated bacteriuria compared to no irrigation, as reported by the Clinical Infectious Diseases journal 1
  • A randomized cross-over trial found that once-daily normal saline irrigation for 10 weeks showed no difference in bacteriuria prevalence, catheter obstructions, or febrile episodes compared to no irrigation, according to the Clinical Infectious Diseases journal 1