Postpartum Antibiotic Prophylaxis After Pyelonephritis in Pregnancy

Rationale for Prophylaxis

• Pyelonephritis during pregnancy represents a complicated UTI that places patients at substantially elevated risk for recurrence, according to the American College of Radiology and European Urology guidelines 1, 2

Important Caveats

• The American College of Obstetricians and Gynecologists advises against using amoxicillin-clavulanic acid for prophylaxis due to its association with an increased risk of necrotizing enterocolitis in neonates when used during pregnancy 3