Clindamycin Prophylaxis for Total Hip Arthroplasty

Dosing Regimen

• The recommended dose of clindamycin for antibiotic prophylaxis in patients undergoing total hip arthroplasty is 900 mg IV administered as a slow infusion, with a single dose being sufficient unless the procedure duration exceeds 4 hours, in which case an additional 600 mg dose should be given 1, 2
• The initial dose of 900 mg IV should be administered as a slow infusion within 60 minutes before surgical incision, ideally 30 minutes before incision 1, 2
• If the surgical procedure exceeds 4 hours, an additional 600 mg IV dose of clindamycin should be administered 1, 2