Ototoxicity and Tinnitus Risk Factors

Medications Associated with Ototoxicity

Platinum-based chemotherapy agents, such as cisplatin, can cause tinnitus in most patients during treatment and 40% of long-term survivors, according to the American Society of Clinical Oncology 1, 2
Aminoglycoside antibiotics, including capreomycin and gentamicin, can cause vestibular disturbances and tinnitus, especially in elderly patients, as reported by the Centers for Disease Control and Prevention 3 and the American Academy of Otolaryngology-Head and Neck Surgery 4
Loop diuretics, when combined with other ototoxic agents, can increase the risk of tinnitus, as noted by the American Society of Clinical Oncology 1, 2

The American Heart Association recommends using the lowest effective dose of celecoxib for the shortest duration necessary to minimize cardiovascular risk 5
Patients with established cardiovascular disease, heart failure, or elevated cardiovascular risk should avoid celecoxib entirely, according to the American College of Cardiology 5
Celecoxib may increase blood pressure by approximately 5 mm Hg, as reported by the American Heart Association 5

The American Gastroenterological Association notes that the gastrointestinal bleeding risk associated with celecoxib increases dramatically with age, with a risk of 1 in 110 for adults over 75 versus 1 in 2,100 for adults under 45 5
The National Kidney Foundation recommends avoiding celecoxib in patients with renal disease or when combining with ACE inhibitors and beta blockers, due to the risk of renal complications 5