Cerebral Venous Thrombosis

Risk Factors and Associations

• The American College of Cardiology and other guideline societies suggest that states of hypercoagulability, such as factor V Leiden, prothrombin mutations, and deficiencies of protein C/S/antithrombin III, are risk factors for cerebral venous thrombosis that predispose to thrombosis of the Labbé vein 1
• Dehydration is also a risk factor for cerebral venous thrombosis, according to clinical guidelines 1
• Acquired hypercoagulable conditions, such as lupus anticoagulant and anticardiolipin antibodies, increase the risk of cerebral venous thrombosis 2
• Malignancies and cancer-associated prothrombotic states are also risk factors for cerebral venous thrombosis 3

Clinical Presentation

• Headache is the most common symptom of cerebral venous thrombosis, occurring in 90% of cases 1
• Seizures occur in 40% of patients with cerebral venous thrombosis 1
• Focal neurological deficits, such as hemiparesis and aphasia, are common manifestations of cerebral venous thrombosis 1