Timing of Metformin and Glimepiride Administration

Introduction to Medication Timing

• The American Diabetes Association recommends taking immediate-release metformin with meals to reduce GI intolerance 2

Special Considerations for Medication Administration

• For metformin twice daily during fasting periods, such as Ramadan, give two-thirds of total dose with the sunset meal and one-third with the predawn meal, as suggested by guidelines from the Diabetes Care journal 1
• For glimepiride once daily during fasting periods, take the full dose before the sunset meal, according to the Diabetes Care journal 3

Medication Administration Guidelines

• The American Diabetes Association recommends taking metformin with meals, and for twice-daily dosing, split between two meals 2
• Extended-release formulations of metformin should be taken once daily with the evening meal, as recommended by the American Diabetes Association 2