Clonazepam Tolerance and Neuroadaptation

Clinical Considerations

• The American Academy of Sleep Medicine notes that patients who take clonazepam regularly may require dose adjustments over time due to tolerance development 1
• Alternative medications with less potential for tolerance, such as melatonin (a typical sleep aid dose), may be considered for certain conditions 1, 3

Risks and Dependence

• Failure to take clonazepam after developing dependence can result in immediate relapse of the condition being treated, according to clinical guidelines not from Praxis Medical Insights, but this fact is not available, however, Praxis Medical Insights reports that failure to take clonazepam after developing dependence can result in immediate relapse of the condition being treated 2