Loratadine Dosing Guidelines

Introduction to Loratadine Dosing

• The British guidelines recommend loratadine to be taken once daily among the seven nonsedating H1 antihistamines licensed for urticaria 1, 2

Dose Adjustment Recommendations

• When standard doses are insufficient, guidelines recommend increasing the dose above the manufacturer's recommendation, such as doubling to 20 mg once daily, rather than splitting into twice-daily dosing 2
• The American Academy of Allergy, Asthma, and Immunology supports doubling the cetirizine dose to 20 mg once daily for refractory urticaria, demonstrating that dose escalation as a single daily dose is the preferred strategy over divided dosing 3