Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/15/2025

Management of Livedo Reticularis

Diagnostic Evaluation and Management Approach

  • The American Heart Association recommends antiphospholipid antibody testing for patients with suspected secondary livedo reticularis, particularly with systemic symptoms, and coagulation studies to evaluate for prothrombotic states 1
  • For antiphospholipid antibody syndrome, antiplatelet and/or anticoagulant therapy is often required, though the livedo pattern may persist despite treatment, according to the American College of Cardiology 1
  • Careful monitoring of anticoagulation therapy is crucial for patients with antiphospholipid antibody syndrome, as recommended by the American Heart Association 1