Pyridoxine Dosing for Vincristine-Induced Polyneuropathy

Dosing Recommendations

• The American Society of Clinical Oncology recommends starting with pyridoxine 100 mg daily for initial treatment of vincristine-induced polyneuropathy, which can be increased to 100 mg twice daily if symptoms persist 1, 2
• For patients with established peripheral neuropathy, experts recommend increasing pyridoxine dose to 100 mg/day 3, 4

Monitoring and Safety Considerations

• Monitor for signs of pyridoxine toxicity, which can include sensory neuropathy with ataxia, areflexia, impaired cutaneous and deep sensations 5
• Avoid prolonged intake of >300 mg/day due to potential neurotoxicity 5