Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/4/2025

Tablet Splitting of Atorvastatin 40 mg

Clinical Practice Considerations

  • High-intensity statin therapy, which includes atorvastatin 40-80 mg, reduces LDL-C by ≥50% and provides significant cardiovascular risk reduction, according to the American College of Cardiology 1
  • When splitting is necessary to achieve the desired dose, atorvastatin is a suitable option compared to some other statins, as stated by the American College of Cardiology 1

Practical Recommendations for Tablet Splitting

  • Monitor lipid levels periodically to ensure therapeutic efficacy is maintained, as recommended by the American College of Cardiology 2