Lacosamide Loading Dose Guidelines

Evidence-Based Dosing Information

• The American College of Emergency Physicians guidelines state that loading dosages for lacosamide have not been studied, though both oral and IV formulations are available and considered safe, with an emphasis on consistent dosing to avoid withdrawal seizures 1, 2, 3
• The American College of Emergency Physicians guidelines note that withdrawal seizures can occur with abrupt discontinuation, emphasizing the importance of consistent dosing 1, 2, 3

Clinical Application Algorithm

• For non-emergent situations, no loading dose is recommended; initiate standard maintenance dosing, as stated by the American College of Emergency Physicians 1, 2, 3