Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/23/2025

Osteochondral Allograft Medical Necessity Determination

Primary Considerations

  • The American Academy of Orthopaedic Surgeons recommends osteochondral allograft for patients with lesions >2.5 cm² who are ≤50 years old, but prerequisites such as supervised physical therapy and meniscal status must be met 1
  • Bipolar lesions (both femoral and tibial involvement) are contraindications for isolated osteochondral allograft, as stated by The Journal of the American Academy of Orthopaedic Surgeons 2

Patient Selection Criteria

  • Patients must have a full-thickness cartilage defect, with a size of ≥2 cm diameter, to be considered for osteochondral allograft, according to The American Academy of Orthopaedic Surgeons 1
  • The defect should be located on the weight-bearing surface, and the patient should have stable knee with negative Lachman, anterior/posterior drawer, and pivot shift tests, as recommended by The Journal of the American Academy of Orthopaedic Surgeons 3

Treatment Algorithm

  • For lesions <2 cm², autograft (mosaicplasty) is preferred, while for lesions 2-6 cm², osteochondral allograft is the first-line treatment, and for lesions >6 cm², osteochondral allograft is preferred due to donor site limitations with autograft, as stated by The American Academy of Orthopaedic Surgeons 1

Mandatory Prerequisites

  • Patients must complete and document at least 6 weeks of supervised, in-person physical therapy, with objective documentation of compliance and failure to achieve adequate symptom relief, as required by The American Academy of Orthopaedic Surgeons 1
  • Definitive imaging assessment of the tibial plateau is necessary to confirm the opposing articular surface is free of significant disease or injury, according to The American Academy of Orthopaedic Surgeons 1
  • Meniscal deficiency must be addressed, either by documenting adequate remaining meniscal tissue or planning concurrent meniscal allograft transplantation, as recommended by The American Academy of Orthopaedic Surgeons 1

REFERENCES

1

Outcomes of Autograft versus Allograft in Pediatric Knee Osteochondral Defects [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

2

joint-preserving surgical options for management of chondral injuries of the hip. [LINK]

The Journal of the American Academy of Orthopaedic Surgeons, 2014

3

aaos appropriate use criteria: treatment of anterior cruciate ligament injuries. [LINK]

The Journal of the American Academy of Orthopaedic Surgeons, 2016