Safety and Dosing Considerations for Doxazosin

Orthostatic Hypotension Risk

• Doxazosin can precipitate orthostatic hypotension, particularly in older adults, increasing the risk of falls and syncope; this safety concern is highlighted in studies published by Circulation (2018) and Hypertension (2018) and reinforced by the American College of Cardiology (2018) 1, 2, 3 – Evidence level: moderate (observational cohort data).

Dose‑Dependent Efficacy in Benign Prostatic Hyperplasia (BPH)

• In the treatment of BPH, doxazosin’s therapeutic effect is dose‑dependent, and clinical trials support titrating the dose up to 8 mg to achieve maximal tolerable efficacy 4 – Evidence level: high (randomized controlled trial).