Medication Dosing Guidelines

Introduction to Medication Dosing

• The appropriate dose of a medication depends on the specific drug, patient characteristics (age, weight, renal function), and indication, with dosing recommendations available in established clinical guidelines 1, 2

Dosing for Adults and Children

• For adults and children >40 kg, the recommended dose is 75 mg twice daily, according to the American Academy of Pediatrics 1, 2
• For children by weight, the recommended doses are:
• For infants, the recommended doses are:
• For preterm infants (based on postmenstrual age), the recommended doses are:

Treatment and Chemoprophylaxis

• For treatment (adults and children ≥7 years), the recommended dose is 10 mg (two 5-mg inhalations) twice daily for 5 days, according to the American Academy of Pediatrics 1, 2, 4
• For chemoprophylaxis (adults and children ≥5 years), the recommended dose is 10 mg (two 5-mg inhalations) once daily for 10 days, as per the American Academy of Pediatrics 1, 2, 4

IV Infusion and Dose Adjustment

• For adults, the recommended dose is 600 mg IV infusion over 15-30 minutes (single dose), according to the American Academy of Pediatrics 2, 4
• For children 2-12 years, the recommended dose is 12 mg/kg IV (up to 600 mg maximum), as per the American Academy of Pediatrics 2, 4
• For patients with creatinine clearance 10-30 mL/min, the recommended doses are:

Special Considerations

• For amantadine and rimantadine (older influenza antivirals), the dose should not exceed 100 mg daily in patients ≥65 years, as recommended by the American Academy of Family Physicians 5
• No dose adjustment is needed for oseltamivir or zanamivir based on age alone, according to the American Academy of Family Physicians 5

Administration and Availability

• Oseltamivir can be administered orally without regard to meals, and is available as capsules (30 mg, 45 mg, 75 mg) and oral suspension (6 mg/mL), as per the American Academy of Pediatrics 1, 2, 3
• Zanamivir is administered by inhalation using a proprietary "Diskhaler" device, and is not recommended for people with chronic respiratory diseases (asthma, COPD) due to risk of bronchospasm, according to the American Academy of Pediatrics 1, 2, 3