Maximum Recommended Dose of Prometrium (Progesterone)
Dosing by Indication
- For continuous combined regimens in postmenopausal women on estrogen therapy, the American College of Obstetricians and Gynecologists recommends doses of 100-200 mg daily of Prometrium, according to the Blood Reviews guideline 1
- For threatened preterm labor, the American College of Obstetricians and Gynecologists recommends higher doses of 400 mg orally every 6 hours for 24 hours, then 400 mg every 8 hours for 24 hours, followed by 300 mg every 8 hours, with a total of 1200 mg/day initially, as stated in the American Journal of Obstetrics and Gynecology 2, 3
- For vaginal administration in women with short cervical length, the American College of Obstetricians and Gynecologists recommends 90-mg gel or 200-mg suppository daily, as stated in the American Journal of Obstetrics and Gynecology 2, 4