Management of Febrile Non-Hemolytic Transfusion Reactions

Temperature Management

• The American Heart Association recommends maintaining normothermia between 36-37°C (96.8-98.6°F) as the target, as temperatures above 37°C are associated with poor outcomes in critically ill patients 2, 5
• The Society of Critical Care Medicine suggests that a temperature of 100.2°F (37.9°C) does not require aggressive cooling measures, and temperatures should not be allowed to drop below 36°C during management, as hypothermia impairs coagulation and increases mortality 3, 4, 5

Monitoring and Assessment

• The Critical Care society recommends monitoring temperature every 15 minutes until stable, in patients with febrile non-hemolytic transfusion reactions 1, 2