Hydroquinone 4% Cream Safety and Efficacy

Adverse Events

• The British Journal of Dermatology reports that common adverse events of hydroquinone 4% cream include contact dermatitis and ochronosis, with prolonged use increasing the risk of the latter 1, 2
• The use of hydroquinone has been associated with theoretical concerns about carcinogenesis, although this remains a topic of debate 1, 2

Treatment Optimization

• Combination therapy with chemical peels, such as glycolic acid 20-70% or salicylic acid 20-30%, may be considered for resistant cases of hyperpigmentation, as suggested by Praxis Medical Insights 3