Buspirone Treatment Protocol for Generalized Anxiety Disorder (GAD)

Initial Dosing and Titration

• The American Academy of Family Physicians recommends starting buspirone at 5 mg twice daily and gradually titrating to an effective dose of 20-30 mg/day in divided doses, with a maximum of 60 mg/day 1
• Buspirone is particularly useful for patients with mild to moderate anxiety/agitation, with a recommended initial dose and titration schedule 1

Clinical Considerations

• Buspirone does not cause tolerance, dependency, or cognitive impairment, making it safer for long-term use, according to the American family physician 1

Special Populations

• Cultural factors may influence treatment response, and culturally adapted treatment approaches may be more effective for certain populations, particularly those who are less acculturated 2, 3