Methylene Blue and Trazodone Interaction

Clinical Management and Alternative Treatments

• The American Journal of Hematology recommends using ascorbic acid (Vitamin C) as an alternative treatment for methemoglobinemia in patients taking trazodone, with dosing ranges from 0.5-10 g in adults 1
• The American Journal of Hematology suggests considering exchange transfusion for severe, life-threatening methemoglobinemia unresponsive to other measures 1