Aripiprazole Dosing Considerations

Special Populations

• Reduce starting doses in older patients and those with hepatic impairment, as recommended by medical guidelines 1

Clinical Considerations for Negative Symptoms

• If treating predominant negative symptoms in schizophrenia, aripiprazole or cariprazine are preferred options when switching antipsychotics, according to The Lancet Psychiatry 2, 3
• Aripiprazole can be used as augmentation in patients not already on a D2 partial agonist, as suggested by The Lancet Psychiatry 3
• This approach requires careful discussion of risks and benefits with the patient, as noted by The Lancet Psychiatry 3

Switching Strategies

• Gradual cross-titration is recommended when switching from other antipsychotics, informed by the half-life and receptor profile of each medication, as recommended by The Lancet Psychiatry 2, 4