Duloxetine Discontinuation Protocol

Tapering Strategy

• A gradual taper of duloxetine over at least 2 weeks is strongly recommended to minimize withdrawal symptoms, according to the Journal of Clinical Oncology 1

Managing Withdrawal Symptoms

• For increased sympathetic activity, α2-adrenergic agonists like clonidine may help reduce symptoms, as suggested by the Mayo Clinic Proceedings 2
• For muscle aches and pain, acetaminophen or NSAIDs can provide symptomatic relief, as suggested by the Mayo Clinic Proceedings 2

Patient Support

• Abandoning patients during the tapering process should be avoided, and instead, ensure continued monitoring and support, as recommended by the Mayo Clinic Proceedings 3