Lorazepam Clearance and Metabolism

Pharmacokinetics and Clearance

The elimination half-life of lorazepam may be increased in patients with renal failure, according to the Critical Care Medicine guidelines 1
Benzodiazepine clearance is reduced in patients with hepatic dysfunction, as stated by the Critical Care Medicine guidelines 1
In infants, the elimination half-life of lorazepam is approximately 40 hours, as reported by the Pediatrics guidelines 2
In children, the elimination half-life of lorazepam is approximately 10.5 hours, as reported by the Pediatrics guidelines 2

When converting from intravenous midazolam to oral lorazepam, the longer half-life of lorazepam must be considered, as recommended by the Pediatrics guidelines 3, 4, 5
For patients requiring sedation assessment, the prolonged clearance time of lorazepam compared to shorter-acting benzodiazepines should be factored into clinical decision-making, according to the Critical Care Medicine guidelines 6, 1

Complete clearance time may be extended in elderly patients or those with impaired renal or hepatic function, as stated by the Critical Care Medicine guidelines 1