Linezolid Dosing Guidelines for Adults

Standard Dosing Regimen

• The standard adult dose of linezolid is 600 mg every 12 hours for most serious Gram-positive infections, including complicated skin and soft tissue infections, pneumonia, bacteremia, according to the Journal of Microbiology, Immunology and Infection 1
• The Infectious Diseases Society of America recommends linezolid 600 mg every 12 hours for the treatment of pneumonia, including community-acquired and hospital-acquired pneumonia, as stated in the Journal of Microbiology, Immunology and Infection 1

Duration of Therapy by Indication

• The American Heart Association recommends a minimum of 6 weeks of linezolid therapy for infective endocarditis caused by resistant enterococci, as published in Circulation 2

Linezolid Dosage and Therapy Duration in Adults

Standard Dosing Recommendations

• The Infectious Diseases Society of America recommends linezolid 600 mg PO/IV twice daily as the standard adult dose for most infections, including complicated skin and soft tissue infections, pneumonia, and bone/joint infections 3, 4, 5

Duration of Therapy

• The optimal duration of therapy depends on the type and severity of infection, with recommended durations including 7-14 days for complicated skin and soft tissue infections 6, 7-14 days for pneumonia 3, 7, a minimum of 8 weeks for osteomyelitis 8, 2 weeks for meningitis 8, and 4-6 weeks for brain abscess, subdural empyema, or spinal epidural abscess 8