Metaxalone Adverse Effects and Contraindications

Gastrointestinal and Hematologic Risks

• Nausea occurs in approximately 5% of patients, according to the Mayo Clinic Proceedings 1
• Metaxalone is contraindicated in patients with significant hepatic or renal dysfunction due to risks of drug-induced anemia and hematologic complications, as stated by the Mayo Clinic Proceedings 2
• Drug-induced anemia has been reported, with the Mayo Clinic Proceedings providing evidence 2

Precautions and Contraindications

• The Mayo Clinic Proceedings recommends that metaxalone should be held on the day of surgical procedures due to potential for increased sedation when combined with anesthetic agents and other CNS depressants 2
• The combination of metaxalone with opiates or other CNS depressants significantly increases sedation risk, according to the Mayo Clinic Proceedings 1 and 2