Low-Dose Lithium for Dementia Prevention

Dosing Considerations

Lower doses of lithium (blood levels 0.2-0.6 mEq/L) may provide neuroprotective benefits while minimizing side effects 1

Lithium should be used with caution in patients with renal impairment 1
For patients with GFR <30 ml/min/1.73 m², lithium should be temporarily discontinued during serious intercurrent illness that increases risk of acute kidney injury 1
NSAIDs should be avoided in patients taking lithium as they can decrease lithium clearance and increase toxicity 1
Regular monitoring of lithium levels is essential, even with low-dose therapy 1

The American Academy of Neurology recommends adherence to a Mediterranean diet to decrease the risk of cognitive decline 2
Physical activity interventions of at least moderate intensity are recommended to improve cognitive outcomes and reduce dementia risk 2
Aerobic exercise and/or resistance training of at least moderate intensity can improve cognition outcomes 2
Addressing hearing impairment is recommended, as it is associated with dementia risk 2