Antiepileptic Medication and Weight Management

Valproate/valproic acid, carbamazepine, gabapentin, and pregabalin are associated with significant weight gain and should be avoided or minimized when weight is a concern, according to the American Diabetes Association 1
The American Gastroenterological Association suggests that switching to lamotrigine can be considered as a weight-neutral alternative for patients on weight-promoting antiepileptics, particularly those with obesity, diabetes, or metabolic syndrome 2
Topiramate may induce weight loss and can be used to counteract weight gain from other medications, as recommended by the American Gastroenterological Association 2

Clinical Considerations for Antiepileptic Medication

When prescribing antiepileptic medications, consider the medication's effect on weight and minimize those associated with weight gain whenever possible, as advised by the American Diabetes Association 1