Tirzepatide Safety During Breastfeeding

General Principles for Medication Use During Breastfeeding

• The American Academy of Pediatrics emphasizes that most medications are compatible with breastfeeding, but a limited number require caution or are contraindicated 1, 2
• The Drugs and Lactation Database (LactMed) from the National Library of Medicine is the most comprehensive resource for medication safety during breastfeeding 1, 2
• Medications with relative infant doses (RIDs) below 10% in breast milk are generally considered safe 3

Clinical Decision Algorithm

• If GLP-1 agonist therapy is deemed essential, consult the LactMed database for any emerging data on newer GLP-1 agonists 1, 2
• Consider temporary cessation of breastfeeding if no alternative exists, though this should be a last resort given breastfeeding benefits 1, 2