Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 7/8/2025

Facial Wound Management

Introduction to Facial Wound Management

  • Facial wounds can be managed with various treatments, including hyaluronic acid gel, which is suitable for superficial wounds that require minimal closure force and for supporting wound healing after the initial wound closure has been established, as recommended by the American Academy of Dermatology 1, 2

Indications for Hyaluronic Acid Gel

  • Hyaluronic acid gel is indicated for treating actinic keratosis on the face, as demonstrated by the safety of diclofenac 3% in 2.5% hyaluronic acid gel, according to the American Academy of Dermatology 1, 2
  • Hyaluronic acid gel can be used for post-procedural wound care after dermatological procedures on the face, as suggested by the American Academy of Dermatology 3
  • Hyaluronic acid gel may be considered as part of an anti-inflammatory emulsion for radiation-induced skin reactions on the face, according to the European Society for Medical Oncology 4

Contraindications and Limitations

  • Hyaluronic acid gel is contraindicated for actively infected facial wounds, heavily contaminated wounds, or deep wounds that require layered closure, as noted by multiple sources 1, 2, 3, 4
  • Dermabond is not recommended for active infections, open wounds with gross contamination, high-tension areas, wounds under significant mechanical stress, mucosal surfaces, areas with high moisture content, and areas with dense hair, as stated by the American Academy of Dermatology and the American Academy of Ophthalmology 5, 6, 7

Application and Post-Application Care

  • A thin layer of hyaluronic acid gel should be applied to the wound surface, and it can be used under appropriate dressings, with reapplication according to manufacturer's instructions, as recommended by the American Academy of Dermatology 3
  • Post-application care includes monitoring for signs of infection, keeping the wound clean and protected, and following up as appropriate for wound assessment, as emphasized by the American Academy of Dermatology 3
  • Dermabond can be applied to small, superficial lacerations, low-tension wounds, and lacerations requiring minimal closure force, using a 30-gauge needle, wooden end of cotton applicator, or micropipette, with the least amount of glue necessary to seal or support the defect, as suggested by the American Academy of Ophthalmology 6
  • A bandage contact lens should be applied after corneal applications to prevent dislocation of glue and provide comfort, and Dermabond can remain in place for up to 6 weeks or longer if applied to a clean and compact base, as noted by the American Academy of Ophthalmology 6

Special Considerations

  • For corneal perforations, leaking descemetoceles may require injection of an air bubble into the anterior chamber to halt leakage temporarily while glue is applied, as recommended by the American Academy of Ophthalmology 6
  • Fibrin glue is not recommended for corneal perforations or descemetoceles, as it biodegrades too rapidly before healing can occur, as stated by the American Academy of Ophthalmology 6
  • De-epithelialization of the wound edges may be necessary, and the wound should be clean and irrigated thoroughly, with hemostasis achieved before application, and the area should be completely dry, as emphasized by the American Academy of Ophthalmology 6