Cardiovascular Safety of Velphoro

Patient Management

• The European Society of Cardiology recommends continuing standard management of hypertension and diabetes according to established guidelines for patients with pre-existing cardiovascular conditions taking Velphoro 1

Medications Known to Cause Bradycardia

• Beta-blockers cause bradycardia through beta-receptor blockade, with rates varying widely across studies, particularly when combined with other AV nodal blocking agents 2, 3
• Calcium Channel Blockers, such as diltiazem and verapamil, are known to cause bradycardia as a recognized adverse effect 2, 3, 5
• Digoxin causes bradycardia and heart block, particularly in the setting of toxicity 5, 7