Memantine Dosage Adjustments in Renal Impairment

Dosing Considerations

• The American Geriatrics Society recommends reducing memantine to 5 mg twice daily in patients with severe renal impairment, as evidenced by a case study where a patient with estimated creatinine clearance of approximately 30 mL/min had memantine reduced from 10 mg twice daily to 10 mg once daily 1
• Elderly patients should be monitored carefully as renal function naturally declines with age, potentially requiring dose adjustment even without documented renal disease, as suggested by the Journal of the American Geriatrics Society 1