Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/26/2025

Mechanism of Action of Risperidone in Treating Psychiatric Disorders

Clinical Applications

  • The American Academy of Sleep Medicine suggests that risperidone's combined 5-HT2 and D2 antagonism contributes to its efficacy in treating PTSD-related nightmares 1, 2
  • The American Academy of Child and Adolescent Psychiatry indicates that risperidone is effective in treating disruptive behavior disorders in children with intellectual disabilities 3, 4

REFERENCES

1

position paper for the treatment of nightmare disorder in adults: an american academy of sleep medicine position paper. [LINK]

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2018

2

position paper for the treatment of nightmare disorder in adults: an american academy of sleep medicine position paper. [LINK]

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2018

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