Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/6/2025

Increasing Vyvanse Dosage for Inadequate ADHD Coverage

  • Morning administration of Vyvanse is recommended to minimize sleep disturbances 1
  • Evaluate therapeutic effects and side effects after 1-2 weeks on the new dose 2
  • Monitor vital signs including blood pressure and heart rate, as stimulants can cause cardiovascular effects 3

Common Pitfalls to Avoid

  • Continuing to increase the dose beyond maximum recommendations (70mg for Vyvanse) when not effective, consider alternative medications instead 1
  • Not allowing sufficient time (at least one week) between dose increases to properly evaluate response 1
  • Overlooking the importance of morning administration to minimize sleep disturbances 1
  • Failing to systematically assess both benefits and side effects during titration 2
  • If the maximum dose of Vyvanse does not provide adequate symptom control, it's essential to reevaluate the diagnosis and consider comorbid conditions that might be affecting treatment response 2

REFERENCES

1

Adderall Dosing Recommendations [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

2

Dose Considerations and Monitoring for Adults with ADHD [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025