Ceftriaxone Safety in Pregnancy

Evidence-Based Safety Profile

• The American Academy of Otolaryngology and Rhinology recommends penicillins and cephalosporins, including ceftriaxone, as the safest antibiotic classes during pregnancy for treating bacterial infections such as acute rhinosinusitis or acute exacerbations of chronic rhinosinusitis, especially when endoscopic evidence of purulence is present 1, 2

Clinical Considerations

• Ceftriaxone can be given for acute bacterial rhinosinusitis or acute exacerbations when endoscopic evidence of purulence is present, and is considered safe for use during pregnancy by the European Respiratory Society and other expert panels 1, 2

Antibiotics to Avoid During Pregnancy

• The American College of Obstetricians and Gynecologists and other medical societies advise against the use of certain antibiotics during pregnancy, including tetracyclines, aminoglycosides, trimethoprim-sulfamethoxazole, fluoroquinolones, and long-term macrolides or doxycycline, due to potential risks to the fetus 1, 2

Ceftriaxone Use in Pregnancy

Antibiotic Classification and Safety

• Ceftriaxone belongs to the cephalosporin class of antibiotics, which is considered one of the safest antibiotic classes during pregnancy, according to the European Respiratory Society 3

Patient Monitoring

• For women with cholestatic liver diseases who are pregnant, laboratory values should be monitored at least once per trimester, as recommended by the European Association for the Study of the Liver 4