Erythromycin Lactobionate Administration Guidelines

Administration Recommendations

• The Centers for Disease Control and Prevention recommends replacing IV therapy with oral erythromycin as soon as clinically possible 1, 2

Prevention of Adverse Effects

• Extending infusion time to 60 minutes reduces gastrointestinal side effects, and pretreatment with glycopyrrolate 0.1 mg IV combined with 60-minute infusion reduces clinically important toxicity by 79% (from 47% to 10%, P=0.007) 1, 2