Pharmacokinetics and Clinical Implications of Oxycodone

Clinical Implications and Precautions

• When combined with acetaminophen, the acetaminophone dose must be monitored to avoid potential hepatic toxicity, as recommended by the National Comprehensive Cancer Network 1
• Prolonged-release oxycodone/naloxone formulations have shown effective analgesia with reduced opioid-induced constipation for long-term use in cancer-related pain, according to the European Society for Medical Oncology 2, 3
• Conversion between opioids should be done carefully as equianalgesic doses may vary between individuals, as advised by the Centers for Disease Control and Prevention 4