Treatment of Diaper Rash with Nystatin

Dosing and Application

• Apply nystatin cream (100,000 units/g) to the affected area 2-4 times daily, continuing for at least 48 hours after symptoms resolve to prevent recurrence, according to the American Academy of Pediatrics guidelines 1
• Treatment duration is typically 7-14 days, as recommended by the American Academy of Pediatrics 1
• Keep the area clean and dry between applications, as suggested by the Infectious Diseases Society of America 2

Important Caveats and Pitfalls

• If no improvement occurs after 7 days of appropriate therapy, consider culture and sensitivity testing, as recommended by the Infectious Diseases Society of America 2
• Non-albicans Candida species may require alternative antifungal agents, according to the Infectious Diseases Society of America 2
• Ensure adequate treatment duration—premature discontinuation is a common cause of recurrence, as noted by the American College of Clinical Pharmacy 3

Preventive Measures During Treatment

• Sterilize pacifiers, bottles, and toys regularly to prevent reinfection, as recommended by the American Academy of Pediatrics 1