Hormone Replacement Therapy and Depression Risk

Introduction to HRT and Depression

• The American College of Obstetricians and Gynecologists recommends that HRT is not used for primary prevention of chronic conditions in postmenopausal women, and if used for menopausal symptom management, the lowest effective dose should be used for the shortest possible time 1
• The North American Menopause Society suggests that women should be informed of all potential risks of HRT, including increased risk for venous thromboembolism, stroke, cardiovascular events, breast cancer, gallbladder disease, and urinary incontinence 1

Benefits of HRT for Transgender Individuals

• The Endocrine Society reports that for transgender individuals receiving gender-affirming hormone therapy, studies have shown decreased depression and anxiety levels following hormone treatment, with a moderate strength of evidence 3, 4