Bupropion and Sexual Libido
Sexual Side Effect Profile of Antidepressants
- Bupropion has a significantly lower rate of sexual adverse events compared to SSRIs such as fluoxetine and sertraline 1, 3
- Paroxetine has higher rates of sexual dysfunction than fluoxetine, fluvoxamine, nefazodone, or sertraline 1, 4
- Most SSRIs commonly cause sexual adverse events including decreased libido and orgasmic dysfunction 3, 4
- Sexual dysfunction is likely underreported in clinical trials of antidepressants 1
Potential Risks and Adverse Effects
- Weak evidence indicates bupropion may be associated with an increased risk for seizures 1, 3
- Common side effects include insomnia and headache 4
- Bupropion has lower rates of somnolence compared to several other antidepressants 1