Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/22/2025

Famotidine Use During Pregnancy

Safety Profile

  • Famotidine is classified as FDA Pregnancy Category B, indicating animal studies have not demonstrated fetal risk, but there are no adequate controlled studies in pregnant women 1

Recommendations for Use

  • The British Journal of Dermatology suggests that when antihistamine therapy is necessary during pregnancy, H2-blockers like famotidine can be considered safe options 2, 3

Important Considerations

  • The European Respiratory Journal states that as with all medications during pregnancy, the use of famotidine should balance maternal benefit against any potential risk 4