Isosorbide-Induced Dyspnea in Patients with Pre-existing Conditions

Clinical Considerations and Management Approach

• The American Heart Association recommends that nitrate therapy, including isosorbide, may improve dyspnea at night and during exercise in some heart failure patients, despite the potential to cause dyspnea as an adverse effect 1, 2
• The American College of Cardiology suggests that implementing a nitrate-free interval of at least 10 hours can minimize tolerance and side effects in patients with heart failure who need nitrate therapy but experience dyspnea 1, 2
• Combining isosorbide with ACE inhibitors or hydralazine may improve tolerance in patients with heart failure, according to the American Heart Association 1, 2