Fertility Treatment with Letrozole

Clinical Evidence

• The American College of Obstetricians and Gynecologists recommends clomiphene citrate as first-line treatment, though recent evidence shows letrozole superiority 2, 3
• Letrozole is particularly valuable in fertility preservation for women with hormone-sensitive cancers, as it enhances ovarian stimulation while keeping estrogen levels near physiologic levels, resulting in similar numbers of eggs and embryos with no impact on cancer-free survival 1
• When gonadotropins are needed after letrozole failure, using low-dose protocols (75 IU or lower) minimizes multiple pregnancy risk 4